49ers vs. Giants Week 3 Best Bets

Published by
Sports Illustrated

By Kyle Wood The Giants stormed back from a 21-point deficit Sunday against the Cardinals to avoid an 0–2 start. Their reward is facing the 49ers on the road four days later without Saquon Barkley. San Francisco, which has the second-best point differential in the NFL (+30), is a 10.5-point home favorite over New York at Levi’s Stadium on Thursday Night Football. The total is set at 45.5 points, which gives the Giants an implied total of 17 points. Daniel Jones is 0–1 in his career against the 49ers, who left MetLife Stadium with a 36–9 victory when these teams last met in 2020. Barkley missed…

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